The Science

Why silicone is the benchmark for scar care.

Topical silicone therapy is the most extensively studied non-invasive scar treatment available, and is recommended internationally as first-line care for linear and hypertrophic scars. Derm Rx delivers medical grade silicone to the healing scar in a light, fast-absorbing gel.

Silicone forms a protective, semi-occlusive layer over the scar. This layer helps regulate hydration in the outer skin layer (the stratum corneum), the mechanism believed to underpin silicone's effect on collagen regulation and abnormal scar formation.

Clinical Benefits

Minimises appearance

Softens scar tissue, reduces raised or thickened (hypertrophic) scarring, and improves colour as the scar matures.

Barrier support

Forms a protective barrier against friction, contamination, and external irritants during healing.

Promotes hydration

Maintains optimal hydration of the stratum corneum, supporting the skin's natural remodelling process.

Skin conditioning

Panthenol and conditioning agents support skin comfort, softness, and symptom relief including itch and tightness.

Clinician tip. Introduce Derm Rx once the wound has fully re-epithelialised. Early, consistent application supports the best long-term cosmetic outcome for the scar.

The Evidence

Backed by three decades of clinical research.

International consensus: silicone as first-line therapy

The International Clinical Recommendations on Scar Management recommend silicone gel sheeting as first-line therapy for linear hypertrophic (surgical and traumatic) scars, based on results from randomised controlled trials.

Mustoe TA, et al. Plast Reconstr Surg. 2002. Updated: Gold MH, et al. Dermatol Surg. 2014;40:817-824.

Meta-analysis of 375 patients across six RCTs

Topical silicone gel significantly reduced scar pigmentation, height, and pliability scores on the Vancouver Scar Scale compared with placebo or no treatment, and performed comparably to silicone sheeting.

Wang F, et al. Int Wound J. 2020;17(3):765-773.

Systematic review of 34 clinical trials

Numerous high-quality RCTs demonstrated that silicone gel sheets and gels significantly improve scar outcomes, concluding silicone is an effective, non-invasive option for both prevention and treatment of scarring.

Morganroth P, et al. Dermatol Surg. 2020.

Prophylactic and curative effect confirmed

A further systematic review and meta-analysis of fluid/liquid silicone gels confirmed both a prophylactic and curative effect on hypertrophic scarring, consistent with the long-established evidence base for silicone sheeting.

Bijlard E, et al. Burns. 2022.

Reduced pain and scar severity

A Wounds Australia (WHAM) evidence summary, incorporating a Cochrane review, found clinical evidence supporting silicone gel sheeting for reducing pain and scar severity in hypertrophic scarring.

Wound Practice & Research. 2025;33(4).

Adherence matters most. Across the published evidence, consistent daily use over 8-12 weeks (or longer for larger or more established scars) is one of the strongest predictors of clinical outcome.